產(chǎn)品英文名稱：Jagged-1 Fc fusion protein
產(chǎn)品中文名稱：Jagged-1 Fc 融合蛋白

Jagged-1 Fc fusion protein產(chǎn)品介紹：
最初在果蠅神經(jīng)系統(tǒng)發(fā)育的研究中發(fā)現(xiàn)Notch信號(hào)途徑的功能。Notch信號(hào)通路是進(jìn)化中高度保守的信號(hào)轉(zhuǎn)導(dǎo)通路，其調(diào)控細(xì)胞增殖、分化和凋亡的功能幾乎涉及所有組織和器官。該通路由Notch受體、配體和CSL蛋白3部分組成。
Jagged-1是notch 配體的受體，是DSL蛋白家族，分子量為180kda的一種蛋白。
Jagged-1 Fc fusion protein產(chǎn)品純度高，通過(guò)human 293 cell純化得到，并經(jīng)過(guò)SDS-PAGE 鑒定純度大于90%。生物活性經(jīng)過(guò)Notch通路報(bào)告基因檢測(cè)，The EC50為200–1000 ng/mL.

Jagged-1 Fc fusion protein產(chǎn)品英文簡(jiǎn)述：
The Notch pathway is an important pathway in stem cell functions. Jagged-1, a ligand for Notch receptors, is a 180kDa type 1 membrane glycoprotein of the Delta/Serrate/Lag2 (DSL) family.
StemRD’s Jagged-1 Fc fusion protein is expressed in human 293 cells as the 1046aa N-terminal extracellular domain of Jagged-1 fused to the Fc domain of human IgG1. This fusion stabilizes Jagged-1 in vitro and in vivo without significant compromise in its biological activity.

• Purity：Greater than 90% as determined by SDS-PAGE analysis
• Biological Activity：Determined by a Notch pathway specific reporter gene assay. EC50s are in the range of 200 – 1000 ng/mL.