產(chǎn)品英文名稱:Thiazovivin
產(chǎn)品中文名稱:Thiazovivin

Thiazovivin Rho相關(guān)激酶抑制劑 產(chǎn)品介紹:
Thiazovivin, N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide,是Rho相關(guān)激酶的抑制劑.它能夠保護(hù)人胚胎干細(xì)胞在缺失ECM環(huán)境中存活,主要是通過調(diào)節(jié)E-鈣粘附素來調(diào)節(jié)細(xì)胞間的相互作用.Thiazovivin 結(jié)合了TGF-beta受體抑制因子和MEK激酶,能夠顯著提高重組效率.Thiazovivin 使用LC/MS層析法檢測,純度大于99%.生物活性已通過在無血清培養(yǎng)基上培養(yǎng)人iPS細(xì)胞得到驗證.

Thiazovivin Rho相關(guān)激酶抑制劑 產(chǎn)品特性:
? Thiazovivin 能夠抑制Rho相關(guān)激酶的活性
? 通過LC/MS檢測,純度大于99%
? 生物活性:在無血清培養(yǎng)基上培養(yǎng)人iPS細(xì)胞得到驗證
? Thiazovivin 只限于科學(xué)應(yīng)用,不能用于人體

Thiazovivin 產(chǎn)品英文簡述:
Thiazovivin, N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide, is a selective inhibitor of Rho-associated kinase (ROCK). It protects human ES cells from death in the absence of ECM by regulating E-cadherin mediated cell-cell interaction. Thiazovivin, in combination with inhibitors of the TGF-beta receptor and the MEK kinases, improves reprogramming efficiency dramatically.

? Purity:Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
? Biological Activity:Tested active for culturing human iPS cells in serum-free medium on Matrigel coated plates.